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Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways
Human Mutation, 10/30/09
Leunen K et al. – BRCA1 ovarian tumors present a different type, number, and length of RCNA; a huge amount of the genome is lost, resulting in important genomic instability. Moreover, important biological pathways are altered differentially when compared to the sporadic group.
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