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Alcohol Stimulates Activation of Snail, Epidermal Growth Factor Receptor Signaling, and Biomarkers of Epithelial-Mesenchymal Transition in Colon and Breast Cancer Cells
Alcoholism, 10/29/09
Keshavarzian A et al. – The authors data support a novel mechanism for alcohol promoting cancer progression through stimulating the EMT program in cancer cells via an EGFR–Snail mediated pathway. This study reveals new pathways for alcohol–mediated promotion of cancer that could be targeted for therapy or prevention of alcohol–related cancers.
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