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From somatostatin to octreotide LAR: evolution of a somatostatin analogue
Current Medical Research and Opinion, 11/05/09

Anthony L et al. – Octreotide is a potent synthetic somatostatin analogue that has become the mainstay of medical therapy for tumor control in neuroendocrine disorders such as acromegaly and GEP–NETs. The development of octreotide LAR offered a further advancement; less frequent dosing provided valuable benefits in quality of life to patients, with equivalent efficacy and tolerability. Moreover, recent results from the PROMID study have confirmed the antiproliferative effect of octreotide LAR in patients with well–differentiated metastatic GEP–NETs of the midgut. New therapeutic uses of octreotide are currently under investigation in a variety of clinical settings.

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