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Janiszewski PM et al. – It is suggested that a large breast size among women may predict type 2 diabetes risk independent of BMI and waist circumference (WC)...In univariate models, breast volume was positively associated with visceral adipose tissue (VAT), intermuscular AT (IMAT), and abdominal and lower–body SAT. After controlling for age, BMI, and WC level, breast volume remained positively associated with VAT and IMAT, such that women with the highest breast volume had ~1.1 and 1.3 kg more VAT and IMAT, respectively, but no more abdominal or lower–body SAT, by comparison to women with the smallest breast volume. Thus, the previously documented association between breast size and type 2 diabetes risk may be in part explained by excess VAT and/or IMAT deposition.

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