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Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes
Molecular Vision, 10/20/09

Barbaro V et al. – These findings demonstrate that HKL could be a suitable scaffold for corneal epithelial stem cells as they were shown to proliferate, express differentiation markers, and bind to the underlying stroma with no alterations in clonogenic potential. HKLs have some advantages over currently used scaffolds, such as the possibility to allow cell growth with no feeder layers, to be freeze dried, and to preserve the integrity and viability of stromal keratocytes.

Exclusive Author Commentary
Enzo Di Iorio, 10/21/09

We consider this as a further step in Cornea Regenerative Medicine towards the development of a tissue-engineered cornea obtained through human epithelial stem cells and natural scaffolds. The replacement of diseased tissues and organs by means of tissue engineering approaches is rapidly becoming a reality!