PA Medical News about Epilepsy, Benign Neonatal

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Neonatal seizures
Current Treatment Options in Neurology, 10/27/09

Glass HC et al. – Seizures in neonates are common and often suggest a serious underlying brain injury such as hypoxia–ischemia, stroke, or hemorrhage. Prolonged video–electroencephalogram (EEG) is the gold standard for detecting seizures, whereas amplitude–integrated EEG may be a convenient and useful screening tool. There is a lack of consensus regarding the relative risk versus benefit for aggressive medical treatment of neonatal seizures. Evidence is increasing that seizures themselves impair brain development, but there is evidence in animal models that commonly used medications are potentially neurotoxic. The authors believe that medical management with a goal of eliminating electrographic and electroclinical seizures is probably warranted.