PA Medical News about Hypercortisolemia

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Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa
Journal of Clinical Endocrinology and Metabolism, 10/21/09

Lawson EA et al. – Anorexia nervosa (AN) and functional hypothalamic amenorrhea (HA) are associated with low bone density, anxiety, and depression. Women with AN and HA have elevated cortisol levels. Significant hypercortisolemia, as in Cushing's disease, causes bone loss. It is unknown whether anxiety and depression and/or cortisol dysregulation contribute to low bone density in AN or HA. Hypercortisolemia is a potential mediator of bone loss and mood disturbance in these disorders.