PA Medical News about nephrotic syndrome

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Zeta chain expression in T and NK cells in peripheral blood of children with nephrotic syndrome
Pediatric Nephrology, 10/28/09

Musial K et al. – The aim of the study was to examine zeta chain expression in CD4+, CD8+ T lymphocytes and NK cells in the peripheral blood of children with INS and to evaluate the effect of anti–CD3+rIL–2 stimulation on the level of zeta chain expression in the INS pediatric population. The altered pattern of zeta expression in fresh NK cells from children with INS in relapse, and the disturbed response of zeta+/CD8+ T cells to anti–CD3+rIL–2 stimulation in relapse, suggests the possible role of this chain in immune dysregulation in INS, particularly with regard to cytotoxic cells.