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Development of genetically engineered human sperm immunocontraceptives
Journal of Reproductive Immunology, 10/28/09
Naz RK – The antibodies inhibit human sperm function in vitro, and their immunocontraceptive effect in vivo is being investigated. If these human scFv antibodies block fertility in vivo they may provide unique and novel immunocontraceptives, a first–in–kind for human use. The multi–epitope contraceptive vaccines and preformed engineered antibodies of defined specificity may eliminate concern related to inter–individual variability of the immune response.
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