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Mitochondrial DNA Damage Is Induced by 7-Ketocholesterol in Human Retinal Pigment Epithelial Cells In Vitro
Investigative Ophthalmology and Visual Science, 11/05/09

Gramajo AL et al. – 7kCh causes significant damage to the full–length intact mtDNA and mitochondrial dysfunction in ARPE–19 cells. These observations suggest that the mitochondria and its DNA may be targets for oxysterol–induced oxidative stress and might play a role in the pathogenesis of retinal diseases.

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