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Developments in the scientific understanding of rheumatoid arthritis
Arthritis Research & Therapy, 10/28/09

Goronzy JJ et al. – Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes preclinical systemic abnormalities and eventually leads to synovial inflammation and destruction of the joint architecture.The end result of RA, destruction of cartilage and bone, appears to be driven by cytokine– and cell contact–induced activation of synoviocytes and monocytic cells, some of which differentiate into tissue–destructive osteoclasts. Targeting mediators involved in this process has greatly improved the management of this chronic inflammatory syndrome.

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