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Nonsteroidal anti-inflammatory drugs
Cancer, 10/16/09

Zell JA et al. – When used regularly or over a prolonged duration before CRC diagnosis, NSAIDs are associated with decreased mortality among female CRC patients.

Methods

Women aged < 85 years participating in California Teachers Study, without prior CRC diagnosis at baseline (1995-1996), and who were diagnosed with CRC during follow-up through December 2005, were eligible for analysis of the association between prediagnosis NSAID use and mortality
NSAID use (including aspirin and ibuprofen) collected through self-administered questionnaire
Cancer occurrence identified through California Cancer Registry linkage
Multivariate Cox proportional hazards regression models were used to estimate HR for death and 95% confidence intervals (95% CIs)

Results

Among 621 CRC patients , 64% reported no prediagnosis regular NSAID use, 17% reported use of 1 to 6 days/week, and 20% reported daily use
Duration of NSAID use < 5 years reported by 17% of patients and use of 5 years was reported by 18%
Regular prediagnosis NSAID use (1-3 days/week, 4-6 days/week, and daily) versus none was associated with improved overall survival (OS) (HR, 0.71; 95% CI, 0.53-0.95) and CRC-specific survival (HR, 0.58; 95% CI 0.40-0.84) after adjustment for clinically relevant factors
Prediagnosis NSAID use ≥ 5 years (vs none) found to be associated with improved OS (HR, 0.55; 95% CI, 0.37-0.84) and CRC-specific survival (HR, 0.40; 95% CI, 0.23-0.71) in adjusted analyses