PA Medical News about Anemia, Sickle Cell Neonatal Screening

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Genetics: Newborn screening for sickle cell anemia
Canadian Family Physician, 10/14/09

Meschino WS et al. – Early identification of sickle cell anemia (SCA) with newborn screening enables antibiotic prophylaxis for Streptococcus pneumoniae, which is one of the early life–threatening complications of untreated disease. Identifying newborns with SCA also facilitates the education of parents and caregivers about early treatment of crises and prevention of complications. Newborn screening might also detect other hemoglobin (Hb) variants, including Hb C, Hb D, and Hb E; however, screening does not test reliably for other hemoglobinopathies, such as beta–thalassemia or Hb H disease. Hemoglobinopathy screening should therefore still be offered to patients and their partners from high–risk ethnic backgrounds, ideally before or early in pregnancy.

Vaccines for preventing invasive salmonella infections in people with sickle cell disease
Cochrane Reviews, 10/23/09 Relevance Score: 82%

Study Targets Stroke Prevention in Children With Sickle Cell Anemia
Internet Source, 10/30/09 Relevance Score: 81%

Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case—control study
The Lancet, 10/20/09 Relevance Score: 81%

Severe sickle cell disease – pathophysiology and therapy
Biology of Blood and Marrow Transplantation, 10/15/09 Relevance Score: 81%

Investigational drugs in sickle cell anemia
Expert Opinion on Investigational Drugs, 10/05/09 Relevance Score: 80%