PA Medical News about Anti-Inflammatory Agents, Non-Steroidal Perioperative Care

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Perioperative Use of Nonsteroidal Anti-Inflammatory Drugs: Results of a UK Regional Audit
Clinical Drug Investigation, 10/15/09

Allen SC et al. – These data reveal that NSAIDs were still widely used as analgesics for many surgical procedures at the time of the audit. Intravenous (IV) NSAID administration is the preferred route because of its reliability and speed of onset. The results of this audit indicated significant use of IV NSAIDs (ketorolac, diclofenac and ketoprofen) not in accordance with manufacturers' recommendations, with some NSAIDs even being used in the absence of a product licence for use by the IV route. This may be due to a lack of a satisfactory licensed product. A new formulation of IV diclofenac may fulfil this currently unmet need.

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Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs
Pharmacological Reports, 10/12/09 Relevance Score: 79%

NSAID switching and short-term gastrointestinal outcome rates after the withdrawal of rofecoxib
Pharmacoepidemiology and Drug Safety, 10/27/09 Relevance Score: 78%

Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique
Journal of Pharmacy and Pharmacology, 10/15/09 Relevance Score: 78%

Pulmonary hypertension and current anesthetic implications
Middle East Journal of Anesthesiology, 10/09/09 Relevance Score: 78%

Use of Nonsteroidal Antiinflammatory Drugs and Risk of Endometrial Cancer
American Journal of Epidemiology, 11/09/09 Relevance Score: 77%