PA Medical News about Aged Acute Coronary Syndrome non-ST-segment elevation

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Acute medical management of the non-ST-segment elevation acute coronary syndromes (NSTE-ACS) in older patients
Archives of Gerontology and Geriatrics, 10/13/09

Docherty A – Older patients with non–ST–segment elevation acute coronary syndrome (NSTE–ACS) represent many clinical challenges. For example diagnosis can be difficult, and comorbidities are common. Furthermore, NSTE–ACS is particularly common in older patients (>60% of acute myocardial infarctions occurring in patients aged 65 years or older) and the mortality associated with NSTE–ACS is particularly high. Despite these many concerns, evidence from clinical trials based on this group of patients is limited. Future prospective clinical trials should therefore more accurately reflect the NSTE–ACS patient population by including more elderly patients and including efficacy endpoints that are relevant for these patients. Furthermore, the lack of clear clinical evidence in this population means that the current treatment guidelines do not fully address the needs of elderly patients. Several recent clinical trials have highlighted some of the main considerations we should make when treating elderly patients with NSTE–ACS. Different therapy options in the pharmacological management of NSTE–ACS in this age group are also discussed.

Temporal trends in the use of invasive cardiac procedures for non-ST segment elevation acute coronary syndromes according to initial risk stratification
Canadian Journal of Cardiology, 11/10/09 Relevance Score: 93%

Comparison of Site-Reported and Core Laboratory-Reported Creatine Kinase-MB Values in Non–ST-Segment Elevation Acute Coronary Syndrome (from the International Trial SYNERGY)
The American Journal of Cardiology, 11/06/09 Relevance Score: 93%

Therapeutic implications of low lymphocyte count in non-ST segment elevation acute coronary syndromes
European Journal of Internal Medicine, 11/06/09 Relevance Score: 93%

Significance of mean platelet volume on prognosis of patients with and without aspirin resistance in settings of non-ST-segment elevated acute coronary syndromes
Blood Coagulation & Fibrinolysis, 11/03/09 Relevance Score: 93%

The association of admission heart rate and in-hospital cardiovascular events in patients with non-ST-segment elevation acute coronary syndromes: results from 135 164 patients in the CRUSADE quality improvement initiative
European Heart Journal, 10/01/09 Relevance Score: 93%