PA Medical News about Insulin

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Practical guidance on intensification of insulin therapy with BIAsp 30: a consensus statement
International Journal of Clinical Practice, 10/19/09

Unnikrishnan AG et al. – Simple treatment algorithms have been developed for (i) patients on basal insulin (human or analogue) once daily or twice daily (BID) who need intensification to BIAsp 30 BID, and (ii) patients on BIAsp 30 once daily or BID who can be intensified to BIAsp 30 BID or TID. As well as these algorithms, specific guidance has been provided on dose transfer (from basal insulin to BIAsp 30), dose split (when intensifying from once daily to BID), and combination oral therapies. In addition, a guide to dose titration is included. The guidelines presented here should enable general or specialist practitioners to use BIAsp 30 to intensify the insulin therapy of patients failing on basal insulin or BIAsp 30 once or twice daily.

Evolution, body composition, insulin receptor competition, and insulin resistance
Preventive Medicine, 11/02/09 Relevance Score: 97%

Comparison of Prandial AIR Inhaled Insulin Alone to Intensified Insulin Glargine Alone and to AIR Insulin Plus Intensified Insulin Glargine in Patients with Type 2 Diabetes Previously Treated with Once-Daily Insulin Glargine
Diabetes Technology & Therapeutics, 10/05/09 Relevance Score: 96%

U-500 Regular Insulin: Clinical Experience and Pharmacokinetics in Obese, Severely Insulin Resistant Type 2 Diabetic Patients
Diabetes Care, 11/16/09 Relevance Score: 95%

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation
Endocrinology, 11/06/09 Relevance Score: 94%

Initiation of Prandial Insulin Therapy with AIR Inhaled Insulin or Insulin Lispro in Patients with Type 2 Diabetes: A Randomized Noninferiority Trial
Diabetes Technology & Therapeutics, 10/02/09 Relevance Score: 94%