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Restoring Barrier Function to Acid Damaged Bladder by Intravesical Chondroitin Sulfate
The Journal of Urology, 10/29/09
Hauser PJ et al. – Chondroitin sulfate binds preferentially to damaged urothelium and restores the impermeability barrier. This suggests that the glycosaminoglycan layer is a major contributor to bladder urothelial impermeability. As determined by binding capacity, the dose applied in humans in Canada (400 mg per instillation) is sufficient to achieve maximum efficacy.
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