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Traumatic brain injury: an overview of pathobiology with emphasis on military populations
Journal of Cerebral Blood Flow & Metabolism, 10/21/09
Cernak I et al. – The pathobiology of primary BINT is extremely complex. It comprises systemic, local, and cerebral responses interacting and often occurring in parallel. Activation of the autonomous nervous system, sudden pressure–increase in vital organs such as lungs and liver, and activation of neuroendocrine–immune system are among the most important mechanisms significantly contributing to molecular changes and cascading injury mechanisms in the brain.
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