PA Medical News about Antihypertensive Agents Mortality Acute Coronary Syndrome

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Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event
Cochrane Reviews, 10/27/09

Perez MI et al. – Nitrates reduce mortality (4–8 deaths prevented per 1000) at 2 days when administered within 24 hours of symptom onset of an acute myocardial infarction. No mortality benefit was seen when treatment continued beyond 48 hours. Mortality benefit of immediate treatment with ACE inhibitors post MI at 2 days did not reach statistical significance but the effect was significant at 10 days (2–4 deaths prevented per 1000). There is good evidence for lack of a mortality benefit with immediate or short–term treatment with beta–blockers and calcium channel blockers for acute myocardial infarction.

Oral Antiplatelet Therapy for Acute and Chronic Management of NSTE ACS: Residual Ischemic Risk and Opportunities for Improvement
Cardiovascular Drugs and Therapy, 11/17/09 Relevance Score: 93%

Acute Coronary Syndromes: Diagnosis and Management, Part II
Mayo Clinic Proceedings, 11/03/09 Relevance Score: 90%

Activated factor XII type A and B-type natriuretic peptide are complementary and incremental predictors of mortality in patients following admission with acute coronary syndrome
Blood Coagulation & Fibrinolysis, 11/03/09 Relevance Score: 90%

Acute medical management of the non-ST-segment elevation acute coronary syndromes (NSTE-ACS) in older patients
Archives of Gerontology and Geriatrics, 10/14/09 Relevance Score: 89%

Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Vascular Health and Risk Management, 10/22/09 Relevance Score: 88%