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A Randomised Placebo Controlled Double Blind Clinical Trial of Cannabis Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a Major Confounding Factor
Diabetes Care, 10/09/09

Selvarajah D et al. – This first ever, trial assessing the efficacy of cannabis has shown it to be no more efficacious than placebo in painful–DPN. Depression was a major confounder and may have important implications for future painful–DPN trials.

Methods

In this randomized controlled trial, 30 subjects with painful–DPN received daily Sativex or placebo.
Primary outcome measure was change in mean daily pain scores and secondary outcome measures included quality of life assessments.

Results

There was significant improvement in pain scores in both groups but mean change between groups was not significant.
There were no significant differences in secondary outcome measures.
Patients with depression had significantly greater baseline pain scores that improved regardless of intervention.

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