PA Medical News about Influenza A Virus, H1N1 Subtype Influenza Vaccines Child

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One Dose of H1N1 Vaccine Immunogenic in High Percentage of Youth Ages 10 to 17. Younger Children Likely Will Need Two Doses
American Family Physician, 10/02/09

Mitchell D – A single 15–microgram dose of a nonadjuvanted vaccine against 2009 H1N1 influenza generated a robust immune response in 76 percent of 10– to 17–year–olds eight to 10 days after immunization. A high percentage of adults ages 18 to 64 years had a robust immune response to a single 15–microgram dose of nonadjuvanted vaccine. The vaccines used in the adult clinical trials were manufactured by CSL Ltd., based in Melbourne, Australia, and Sanofi Pasteur Inc., (2–page PDF; About PDFs) based in Swiftwater, Pa. Similar results seen with Sanofi Pasteur's H1N1 vaccine for children ages 10 to 17 years represented good news in terms of vaccine supply and efficacy. Results were not as favorable, however, in younger children. A strong immune response was reported in 36 percent of kids 3 years to 9 years of age who received single 15–microgram dose of the H1N1 vaccine and in only 25 percent of children 6 months to 35 months old who received one such dose. Immune response likely would increase in all age groups closer to 21 days after vaccination. Children ages 6 months to 9 years likely will need two H1N1 doses 21 days apart. Healthy children ages 2 and older can receive live attenuated influenza vaccine, or LAIV, as a nasal spray. Inactivated seasonal flu vaccine and inactivated H1N1 vaccine likely can be administered on the same day via injections in different arms.

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