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Protective Effects of Rosa damascena and its Active Constituent on A-beta(25–35)-induced Neuritic Atrophy
Evidence-based Complementary and Alternative Medicine , 10/07/09
Awale S et al. – The authors observed that the chloroform extract of the Rosa damascena significantly induced the neurite outgrowth activity and inhibited the A–beta(25–35)–induced atrophy and cell death. Further workup led the isolation of a very long polyunsaturated fatty acid having molecular formula C37H64O2 as an active constituent. The structure of this compound was established by extensive analysis of fragmentations observed in EI–MS mode.
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