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See Latest ArticlesOutpatient intravenous ketamine for the treatment of complex regional pain syndrome: A double-blind placebo controlled study
Pain, 09/25/09
Schwartzman RJ et al. – The results of this study warrant a larger randomized placebo controlled trial using higher doses of ketamine and a longer follow–up period.
Methods- Randomized double–blind placebo controlled trial.
- Before treatment, after informed consent was obtained, each subject was randomized into a ketamine or a placebo infusion group.
- Study subjects were evaluated for at least 2 weeks prior to treatment and for 3 months following treatment.
- All subjects were infused intravenously with normal saline with or without ketamine for 4 h (25 ml/h) daily for 10 days. The maximum ketamine infusion rate was 0.35 mg/kg/h, not to exceed 25 mg/h over a 4 h period.
- Subjects in both the ketamine and placebo groups were administered clonidine and versed.
- Intravenous ketamine administered in an outpatient setting resulted in statistically significant reductions in many pain parameters.
- Subjects in the placebo group demonstrated no treatment effect in any parameter.
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