PA

Your Article Summary

See Latest Articles

Systematic Review: Glucose Control and Cardiovascular Disease in Type 2 Diabetes
Annals of Internal Medicine, 09/15/09

Kelly TK et al. – Intensive glucose control reduced the risk for some cardiovascular disease outcomes (such as nonfatal myocardial infarction), did not reduce the risk for cardiovascular death or all–cause mortality, and increased the risk for severe hypoglycemia.

• Studies were retrieved by systematically searching the MEDLINE database (January 1950 to April 2009) with no language restrictions.
• Two independent reviewers screened abstracts or full–text articles to identify randomized trials that compared clinical outcomes in patients with type 2 diabetes receiving intensive glucose control and those receiving conventional glucose control.
• Two investigators independently abstracted data on study variables and outcomes, including severe hypoglycemia, cardiovascular disease, and all–cause mortality.

• 5 trials involving 27 802 adults were included.
• Intensive glucose targets were lower in the 3 most recent trials.
• Summary analyses showed that compared with conventional control, intensive glucose control reduced the risk for cardiovascular disease but not cardiovascular death or all–cause mortality.
• Intensive glucose control increased the risk for severe hypoglycemia.
• Limitation: Summary rather than individual data were pooled across trials.

Related Articles

See all related articles

Neopterin predicts the risk for fatal ischemic heart disease in type 2 diabetes mellitus: Long-term follow-up of the HUNT 1 study
Atherosclerosis, 11/13/09    Relevance Score: 96%

Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
Arthritis Care and Research, 11/03/09    Relevance Score: 96%

Value of C-reactive protein and IL-6 measurements in type 1 diabetes mellitus
Archives of Medical Science, 11/02/09    Relevance Score: 96%

Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance, prediabetes, and type 2 diabetes
Gender Medicine, 10/21/09    Relevance Score: 96%

Defining the Importance of Daily Glycemic Control and Implications for Type 2 Diabetes Management
Postgraduate Medicine, 10/05/09    Relevance Score: 96%

Today in Cardiology...keeping you current

Receive free subspecialty "5-minute updates" via email

Extraskeletal effects of vitamin D in older adults: Cardiovascular disease, mortality, mood, and cognition
The American Journal of Geriatric Pharmacotherapy, 03/18/10

Serum Phosphorus Levels and the Spectrum of Ankle-Brachial Index in Older Men
American Journal of Epidemiology, 03/18/10

Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure
Metabolism-Clinical and Experimental, 03/18/10

 See all of Cardiology

Today in Endocrinology...keeping you current

Receive free subspecialty "5-minute updates" via email

Angiogenesis-inhibitors for metastatic thyroid cancer
Cochrane Reviews, 03/18/10

The economics of obesity
American Journal of Clinical Nutrition, 03/18/10

Reviewing statin therapy in diabetes - Towards the best practise
Primary Care Diabetes, 03/18/10

 See all of Endocrinology

Today in Preventive Medicine...keeping you current

Receive free subspecialty "5-minute updates" via email

Extraskeletal effects of vitamin D in older adults: Cardiovascular disease, mortality, mood, and cognition
The American Journal of Geriatric Pharmacotherapy, 03/18/10

Vegetarian diets and childhood obesity prevention
American Journal of Clinical Nutrition, 03/18/10

Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study
Primary Care Diabetes, 03/18/10

 See all of Preventive Medicine