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Pain and fibromyalgia
Continuing Education in Anaesthesia, Critical Care & Pain , 09/14/09

Dedhia JD et al. – Fibromyalgia is a common chronic pain syndrome characterized by widespread pain, tenderness, and generalized hypersensitivity to painful stimuli.

Pain, fatigue, and sleep disturbance are present in most patients with this condition.
The pathophysiology is not well understood. Central sensitization, abnormalities in descending inhibitory pain pathways, neurotransmitter release, neurohumoral dysfunction, and psychological abnormalities are suggested aetiological mechanisms.
Diagnosis is based on the clinical criteria set out by the American College of Rheumatology, physical examination, and exclusion of other causes for symptoms attributed to fibromyalgia.
The treatment of this syndrome should be individualized and includes pharmacological and other therapies.