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Liao H–T et al. – Undifferentiated spondyloarthritis (USpA) include incomplete forms or early phases of definite seronegative spondyloarthritis (SpA) and cases of spondyloarthritis that remain undifferentiated. The treatment of SpA is more conditioned by the disease localization. Non–steroidal anti–inflammatory drugs and disease–modifying antirheumatic drugs are the main therapeutic agents for the treatment of peripheral arthritis in USpA. Tumor necrosis factor–alpha (TNF–alpha) has been detected in sacroiliac joints of patients with SpA.

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