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A potential therapeutic agent for hepatic fibrosis
EurekAlert, 08/26/09
Accumulating evidence suggests that connective tissue growth factor plays a central role in fibrotic conditions in many organ systems. Fibrosis is a scarring condition that is characterized by excessive collagen production that impedes normal cell function and can cause organ dysfunction and failure. A hallmark of fibrosing injury in the liver is the activation of hepatic stellate cells which become highly proliferative, synthesize increased levels of transforming growth factor (TGF)–beta and CCN2, and produce excessive amounts of collagen.
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