PA Medical News about allergic asthma; omalizumab

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Omalizumab: the evidence for its place in the treatment of allergic asthma
Core Evidence, 08/17/09

McNicholl DM et al. – There is clear evidence to show that omalizumab is effective in reducing the rate of asthma exacerbations, inhaled corticosteroid dose, and the need for rescue medication in patients with allergic asthma. Clinical data indicate beneficial effects on patient–reported symptoms and perceived quality of life, as well as a reduction in unscheduled healthcare visits. There is little evidence to suggest omalizumab may enhance lung function or reduce the requirement for oral corticosteroids. Omalizumab has a favorable safety profile, although anaphylaxis has occurred. A study in children showed similar results to those achieved in adults and adolescents, with fewer asthma exacerbations and school days missed. Omalizumab may be cost effective in patients when used as add–on therapy to inhaled corticosteroids and long–acting beta2 agonists (LABA).