PA Medical News about childhood leukaemias

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The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
Molecular Cancer, 07/02/09

Hesson LB et al. - The study shows the hypermethylation profile of RASSF genes in leukaemias is distinct from that of solid tumours and represents the first report of inactivation of RASSF6 or RASSF10 in cancer. These data show epigenetic inactivation of RASSF6 and RASSF10 is an extremely frequent event in the pathogenesis of childhood leukaemia. This study also warrants further investigation of the newly identified RASSF member RASSF10 and its potential role in leukaemia.

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Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
British Journal of Haematology, 10/05/09 Relevance Score: 68%

Childhood cancer mortality in Europe, 1970–2007
European Journal of Cancer, 10/14/09 Relevance Score: 67%

Extracorporeal membrane oxygenation as a rescue therapy for leukaemic children with pulmonary failure
British Journal of Haematology, 10/16/09 Relevance Score: 64%

Prognostic relevance of TLX3 (HOX11L2) expression in childhood T-cell acute lymphoblastic leukaemia treated with Berlin–Frankfurt–Münster (BFM) protocols containing early and late re-intensification elements
British Journal of Haematology, 10/16/09 Relevance Score: 64%

Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study
Journal of Clinical Oncology, 10/06/09 Relevance Score: 46%