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Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis
Carcinogenesis, 07/02/09

Rosenthal DS et al. - Id2 is a member of the helix-loop-helix (HLH) family of transcription regulators known to antagonize basic HLH transcription factors and proteins of the retinoblastoma tumor suppressor family and is implicated in the regulation of proliferation, differentiation, apoptosis and carcinogenesis. The results tie together the previously observed misregulation of Id2 with a novel mechanism for tumorigenesis.

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APC promoter hypermethylation is an early event in endometrial tumorigenesis
Cancer Science, 11/16/09 Relevance Score: 88%

RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1
Oncogene, 10/26/09 Relevance Score: 88%

Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis
Gastroenterology, 10/07/09 Relevance Score: 88%

Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
Journal of Hematology & Oncology, 10/30/09 Relevance Score: 85%

High Expression of the PAX3-FKHR Oncoprotein Is Required to Promote Tumorigenesis of Human Myoblasts
American Journal of Pathology, 11/09/09 Relevance Score: 83%