PA Medical News about myeloma cells

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Dexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells
Leukemia and Lymphoma, 07/02/09

Kim SW et al. - Incubation of cells under hypoxic conditions (1% O2) also induced upregulation of CXCR4 in the cytoplasm and on the cell surface and enhanced chemotaxis in response to stromal cell-derived factor-1 (SDF-1). Cell surface CXCR4 expression was more prominent in annexin V-positive apoptotic cells. Given the roles of the SDF-1/CXCR4 axis in the development and progression of myeloma, CXCR4-downregulating agents may enhance the antitumor effects of dexamethasone.

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Multiple myeloma and cutaneous anaplastic large T-cell lymphoma in the same patient: Is there a causal relation
Journal of Cutaneous Pathology, 11/09/09 Relevance Score: 67%

Initial cytoreductive treatment with thalidomide plus bolus vincristine/doxorubicin and reduced dexamethasone followed by autologous stem cell transplantation for multiple myeloma
Investigational New Drugs, 10/23/09 Relevance Score: 67%

Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma
American Journal of Hematology, 11/10/09 Relevance Score: 66%

Primary plasma cell leukemia
Cancer, 11/04/09 Relevance Score: 66%

Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target
Cancer Cell, 10/12/09 Relevance Score: 66%