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Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary
New England Journal of Medicine, 06/25/09

Shah SP et al. - Whole-transcriptome sequencing of four GCTs identified a single, recurrent somatic mutation (402C-->G) in FOXL2 that was present in almost all morphologically identified adult-type GCTs. Mutant FOXL2 is a potential driver in the pathogenesis of adult-type GCTs.

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Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2
Fertility and Sterility, 11/17/09 Relevance Score: 84%

Gonadotropin releasing hormone antagonists suppress aromatase and anti-Mullerian hormone expression in human granulosa cells
Fertility and Sterility, 11/10/09 Relevance Score: 84%

Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells
Journal of Clinical Endocrinology and Metabolism, 11/06/09 Relevance Score: 83%

Variable F-18 fluorodeoxyglucose Avidity of Metastatic Recurrent Adult Granulosa Cell Tumor
Clinical Nuclear Medicine, 10/07/09 Relevance Score: 80%

Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant
Fertility and Sterility, 10/06/09 Relevance Score: 80%