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See Latest ArticlesPeculiar violaceous, atraumatic rash
The Clinical Advisor, 06/05/09
Simon EO - The diagnosis was fixed drug eruption (FDE) induced by naproxen. FDE is defined as a peculiar onset of round or oval, edematous, dusky red macules or plaques on the skin and/or mucous membranes. This patient had a circumscribed, well-demarcated, violaceous 8- x 3-cm plaque with central hypopigmentation located just medial and inferior to the left nipple. In some patients, the lesions can be accompanied by burning or itching. Treatment of FDE primarily focuses on avoiding the offending agent. Additional treatment options include topical corticosteroids for mild lesions; wet compresses or antimicrobial ointment, such as bacitracin, for erosive lesions; and systemic steroids for severe generalized bullous lesions. Skin changes, such as post-inflammatory hyperpigmentation, generally spontaneously resolve within weeks of drug withdrawal but may recur within hours of repeat exposure.
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