PA Medical News about Cyclooxygenase Inhibitors

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Does the Use of Cyclooxygenase Inhibitors Delay Fracture Healing
The Internet Journal of Academic Physician Assistants, 01/05/09

Lopez M - It has been hypothesized that the use of COX inhibitors does have a deleterious effect on fracture healing. This survey analyzes whether or not the use of cyclooxygenase inhibitors has a negative effect on fracture healing. A computerized literature search was done regarding the effects that NSAIDs have on fracture healing. Trials chosen for this survey involved the effect of COX inhibitors on the long bones of rats. Several trials done have shown that the use of COX-1 inhibitors does in fact delay fracture healing. However, other studies found that COX-2 inhibitors, due to their selectivity, do not delay fracture healing. The studies selected showed that use of COX-2 inhibitors do not have as much of a detrimental effect as the COX-1 inhibitors.