PA Medical News about Cyclooxygenase Inhibitors

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Does the Use of Cyclooxygenase Inhibitors Delay Fracture Healing
The Internet Journal of Academic Physician Assistants, 01/05/09

Lopez M - It has been hypothesized that the use of COX inhibitors does have a deleterious effect on fracture healing. This survey analyzes whether or not the use of cyclooxygenase inhibitors has a negative effect on fracture healing. A computerized literature search was done regarding the effects that NSAIDs have on fracture healing. Trials chosen for this survey involved the effect of COX inhibitors on the long bones of rats. Several trials done have shown that the use of COX-1 inhibitors does in fact delay fracture healing. However, other studies found that COX-2 inhibitors, due to their selectivity, do not delay fracture healing. The studies selected showed that use of COX-2 inhibitors do not have as much of a detrimental effect as the COX-1 inhibitors.

Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter OATP2A1 expressed in human gastroduodenal mucosa
Journal of Pharmacology and Experimental Therapeutics, 10/26/09 Relevance Score: 68%

Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine and streptozotocin-induced hyperalgesia
Pharmacological Reports, 10/12/09 Relevance Score: 67%

Update on the Management of Pain in Arthritis and the Use of Cyclooxygenase-2 Inhibitors
Current Pain and Headache Reports, 11/06/09 Relevance Score: 66%

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids
Pain, 11/02/09 Relevance Score: 66%

Cyclooxygenase-2 Inhibitors Down-regulate Osteopontin and Nr4a2-New Therapeutic Targets for Colorectal Cancers
Gastroenterology, 10/07/09 Relevance Score: 66%