The PTEN–AKT3 signaling cascade as a therapeutic target in melanoma
Madhunapantula SRV et al. - This review provides an overview of the PI3 kinase pathway focusing specifically on two members of the pathway, called PTEN and Akt3, which play important roles in melanoma development. Mechanisms leading to deregulation of these two proteins and therapeutic implications of targeting this signaling cascade to treat melanoma are detailed in this review. [more...]
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