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Tobin JA et al. – Symptomatic medication overuse (SMO) tripled the risk of occipital nerve block (ONB) failure, possibly because medication overuse headache does not respond to ONB. SMO increased ONB failure rate more in migraineurs than in those with occipital neuralgia, possibly because migraineurs are particularly susceptible to medication overuse headache. This effect was much more pronounced in non–intractable migraineurs than in intractable migraineurs.

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