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See Latest ArticlesKetorolac But Not Morphine Exerts Inflammatory and Metabolic Effects in Synovial Membrane After Knee Arthroscopy: A Double-Blind Randomized Prospective Study Using the Microdialysis Technique
Regional Anesthesia and Pain Medicine, 11/04/09
Stalman A et al. – To the authors' knowledge, this is the first study on the local metabolic and inflammatory effect of intra–articularly administered morphine or ketorolac. For the first time, glutamate was studied in synovial tissue, and our results suggest that local release of glutamate may be important for nociception and inflammation. The effects of ketorolac on PGE2 implicates a local effect on inflammation and possibly, also nociception, but it should be remembered that 60 mg of ketorolac given intra–articularly also has a systemic effect. Release of glycerol after administration of ketorolac may indicate a toxicity of nonsteroidal anti–inflammatory drugs that must be further evaluated.
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