Evidence-Based Knee Injections for the Management of Arthritis
Pain Medicine,  Evidence Based Medicine  Clinical Article

Cheng OT et al. – The authors conclude that strong evidence supports the use of intraarticular knee injection as a valuable intervention in the continuum of management of arthritis between conservative treatment and knee surgeries.

Methods
  • The authors systematically searched PUBMED/MEDLINE and the Cochrane databases for articles published on knee injections and evaluated their level of evidence and recommendations according to established criteria.

Results
  • The evidence supports the use of intraarticular corticosteroid injections for rheumatoid arthritis (1A+ Level), osteoarthritis (1A+ Level), and juvenile idiopathic arthritis (2C+ Level).
  • Pain relief and functional improvement are significant for months up to 1 year after the injection.
  • Triamcinolone hexacetonide offers an advantage over triamcinolone acetonide and should be the intraarticular steroid of choice (2B+ Level).
  • Intraarticular injection of hyaluronate may provide longer pain relief than steroid injection in osteoarthritis (2B+ Level).
  • It can also be effective for rheumatoid arthritis knee pain (1A+ Level).
  • However, it is only recommended for patients with significant surgical risk factors and for patients with mild radiographic disease in whom conservative treatment has failed (2B± Level).
  • Botulinum toxin type A injection is effective in reducing arthritic knee pain (2B+ Level), and so is tropisetron (2B+ Level) and tanezumab (2B+ Level).
  • The new agents, such as rAAV2–TNFR:Fc, SB–210396/CE 9.1, and various radioisotopes have provided various degrees of success, but their long–term safety and efficacy remains to be determined.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pain Management

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pain Management Articles

1 Transforaminal versus parasagittal interlaminar epidural steroid injection in low back pain with radicular pain: a randomized, double-blind, active-control trial Full Text Pain Physician, July 23, 2014    Free full text

2 Effectiveness of duloxetine compared with pregabalin and gabapentin in diabetic peripheral neuropathic pain The Clinical Journal of Pain, September 12, 2014    Clinical Article

3 Treatment of common low back pain: A new approach to an old problem Pain Practice, June 25, 2014    Clinical Article

4 Effect of vitamin D on musculoskeletal pain and headache: A randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway Pain, September 26, 2014    Clinical Article

5 Intradiskal methylene blue treatment for diskogenic low back pain PM&R, August 6, 2014    Clinical Article

6 Analgesic use in older adults with back pain: the BACE study Pain Medicine, August 7, 2014    Clinical Article

7 Conservative treatments for lumbar radicular pain Current Pain and Headache Reports, September 19, 2014    Review Article

8 Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010 JAMA Internal Medicine, September 10, 2014    Clinical Article

9 Low back pain in children and adolescents: A systematic review and meta-analysis evaluating the effectiveness of conservative interventions European Spine Journal, August 29, 2014    Evidence Based Medicine    Review Article    Clinical Article

10 Prednisone for emergency department low back pain: A randomized controlled trial The Journal of Emergency Medicine, May 29, 2014    Clinical Article

11 Efficacy of memantine in the treatment of fibromyalgia: a double-blind randomised controlled trial with 6-month follow-up Pain, September 16, 2014    Clinical Article

12 Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain Full Text Pain Physician, July 23, 2014    Free full text

13 Exercise and physical activity in older adults with knee pain: a mixed methods study Rheumatology, September 17, 2014    Clinical Article

14 Management of persistent pain in the older patient: A clinical review JAMA, September 10, 2014    Clinical Article

15 The effect of daily walking steps on preventing neck and low back pain in sedentary workers: a 1-year prospective cohort study European Spine Journal, September 15, 2014    Clinical Article

16 Lumbar fusion versus nonoperative management for treatment of discogenic low back pain: A systematic review and meta-analysis of randomized controlled trials Journal of Spinal Disorders & Techniques, June 30, 2014    Evidence Based Medicine    Review Article    Clinical Article

17 Midwives and gynecologists: knowledge about sterile water injections for pain relief in labor Pain Management Nursing, September 11, 2014    Clinical Article

18 Fasinumab (REGN475), an antinerve growth factor monoclonal antibody, for the treatment of acute sciatic pain: results of a proof-of-concept study Full Text Journal of Pain Research, September 2, 2014    Free full text    Clinical Article

19 Transforaminal versus interlaminar approaches to epidural steroid injections: a systematic review of comparative studies for lumbosacral radicular pain Full Text Pain Physician, July 29, 2014    Free full text    Review Article
Exclusive Author Commentary

20 Opioids versus physical therapy for management of chronic back pain Full Text The Journal for Nurse Practitioners , September 26, 2014    Free full text    Clinical Article

Indexed Journals in Pain Management: more

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close