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Association between osteoporosis and urinary calculus: evidence from a population-based study
Osteoporosis International,
Keller JJ et al. – This study succeeded in detecting an association between osteoporosis and prior urinary calculus (UC). In addition, the findings were consistent and significant regardless of stone location.
Methods- The authors first identified 39,840 cases ≥40 years who received their first–time diagnosis of osteoporosis between 2002 and 2009 and then randomly selected 79,680 controls.
- They used conditional logistic regression analyses to compute the odds ratio (OR) and the corresponding 95 % confidence interval (CI) for having been previously diagnosed with UC between cases and controls.
- The OR of having been previously diagnosed with UC for patients with osteoporosis was 1.66 (95 % CI = 1.59–1.73) when compared to controls after adjusting for geographic location, urbanization level, type I diabetes mellitus, coronary heart disease, hyperlipidemia, rheumatoid arthritis, stroke, renal disease, Parkinson's disease, hyperthyroidism, chronic hepatopathy, Cushing's syndrome, malabsorption, gastrectomy, obesity, and alcohol abuse/alcohol dependence syndrome.
- The results consistently showed that osteoporosis was significantly associated with a previous diagnosis of UC regardless of stone location; the adjusted ORs of prior kidney calculus, ureter calculus, bladder calculus, and unspecified calculus when compared to controls were 1.71 (95 % CI = 1.61–1.81), 1.60 (95 % CI = 1.47–1.74), 1.59 (95 % CI = 1.23–2.04), and 1.69 (95 % CI = 1.59–1.80), respectively.
