The Metabolism of Opioid Agents and the Clinical Impact of Their Active Metabolites
The Clinical Journal of Pain, 10/12/2011
Smith HS et al. – A greater appreciation of the metabolism of commonly prescribed opioid analgesics and the impact of their active metabolites on efficacy and safety may aid prescribers in tailoring care for optimal outcomes.Methods
- This is a narrative review of the metabolism of various opioids that will highlight the impact of their active metabolites, and the potential impact of cytochrome P450 activity on analgesic activity.
- An understanding of “opioid metabolic machinery,” cytochrome P450 activity, and drug–drug interactions in the context of opioid selection may benefit clinicians and patients alike.