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COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia
Pain, 12/10/2010
Finana PH et al. – The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process, which has been previously characterized in a sample of postoperative shoulder pain patients. Further, the findings advance our understanding of the role of COMT in FM, suggesting that genetic variation in the val158met polymorphism may affect FM pain through pathways of pain-related cognition.
Methods- 45 women with fibromyalgia (FM)
- 30-day electronic diary assessment, recording daily ratings of pain and 2 forms of maladaptive coping: pain catastrophizing and pain attention
- Genotyped for val158met single nucleotide polymorphism (rs4680) in catechol-O-methyltransferase (COMT) gene
- COMT genotype moderated daily relations of both maladaptive coping processes and pain
- FM women with homozygous met/met genotype evidenced more pain on days when pain catastrophizing elevated relative to heterozygous and homozygous val158 carriers
- FM women with homozygous met/met genotype evidenced more pain on days when pain attention elevated relative to those with homozygous val/val genotype
- Evidence is presented to suggest independent effects