Intravenous ketamine compared with diclofenac suppository in suppressing acute postoperative pain in women undergoing gynecologic laparoscopy

Journal of Anesthesia, 05/14/2012

Diclofenac 100–mg suppositories were more effective in suppressing acute pain than 0.15mg/kg intravenous ketamine in women undergoing elective gynecologic laparoscopy, with fewer untoward complications.


  • In a double–blind, randomized clinical trial, 80 patients were selected and entered the study.
  • After the induction of general anesthesia, one group received 0.15mg/kg intravenous ketamine and the other group received a 100–mg rectal diclofenac suppository.
  • The two groups were compared regarding acute pain scores, postoperative morphine requirements, and untoward complications.


  • Pain scores and morphine requirements were lower in the rectal diclofenac suppository group at the 1st, 3rd, and 6th postoperative hours.
  • Higher incidences of postoperative nausea and vomiting (PONV), delusions, and oral secretions were observed in the ketamine group.

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