Headache: The Journal of Head and Face Pain, 04/24/2012Breslau N et al.
The results suggest the possibility that pain severity might account in part for the increased risk of suicide attempt associated with migraine.
A cohort of persons with migraine (n = 496), non–migraine severe headaches (n = 151), and controls with no history of severe headache (n = 539) was randomly selected from the general community, assessed in 1997 and reassessed 2 years later.
Persons with migraine had an increased risk of suicide attempt during the 2–year follow–up period, compared with controls.
Odds ratio, adjusted for sex, psychiatric disorder, and previous history of suicide attempt at baseline was 4.43 (95% confidence interval [CI] 1.93, 10.2).
Persons with non–migraine headache of comparable intensity and disability also had an increased risk of suicide attempt, compared to controls: odds ratio, adjusted for the same covariates, was 6.20 (95% CI 2.40, 16.0).
The difference between the 2 estimates was not significant.
In the entire sample, headache severity at baseline predicted suicide attempt: a difference of 1 standard deviation (SD) in pain score increased the risk of suicide attempt by 79%, adjusting for sex and psychiatric disorders.
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