Oral triptans in the preventive management of cluster headache

Current Pain and Headache Reports, 03/05/2012

This review focuses on the potential use of oral triptans in the prophylaxis of cluster headache.

  • Cluster headache is a rare primary neurovascular headache and a severe pain condition with unilateral headache over 15–180 minutes and concomitant unilateral autonomic symptoms.
  • The detailed pathophysiology of the condition is still unclear.
  • Only a few evidence–based therapeutic options for acute therapy and the preventive management of the disease are available.
  • Triptans, in particular sumatriptan 6 mg subcutaneously, are highly effective for acute treatment.

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