Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever
The Journal of Allergy and Clinical Immunology, 07/31/2012
Hatzler L et al. – The IgE response against grass pollen molecules can start years before disease onset as a weak monosensitization or oligosensitization phenomenon. It can increase in serum concentration and complexity through a “molecular spreading” process during preclinical and early clinical disease stages. Testing IgE sensitization at a preclinical stage facilitates prediction of seasonal allergic rhinitis at its molecular monosensitization or oligosensitization stage.