Expression profiles of regulatory and helper T-cell-associated genes in nasal polyposis
Li CW et al. – Upregulation of FOXP3+–inducible Treg cells and downregulation of Th2 and Th17 markers in Nasal polyposis (NP) indicate a regulatory response occurring at a site of persistent mucosal inflammation. However, immune regulation fails to control the underlying tissue pathology. Expression of T–reg/Th2 markers after glucocorticosteroid (GC) treatment was unaltered, suggesting that T–cell–driving NP inflammatory mediators are GC resistant.