Lysyl oxidase and enhancement of cell proliferation and angiogenesis in oral squamous cell carcinoma

Head & Neck, 03/19/2012

Lysyl oxidase (LOX) overexpression increased proliferation and proliferating cell nuclear antigen expression. High LOX expression clones increased tumor size in a tumorigenesis model. The microvascular numbers were higher in LOX overexpression tumors than in control tumors. LOX can induce cell proliferation and angiogenesis in oral squamous cell carcinoma.

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