Clinical evaluation of Lugol's iodine staining in the treatment of stage I–II squamous cell carcinoma of the tongue
International Journal of Oral and Maxillofacial Surgery, 05/20/2011
Umeda M et al. – Those with a positive or a close margin for squamous cell carcinoma(SCC) underwent additional resection 2–4 weeks after surgery; one was proved histologically to have residual SCC. No patients developed local recurrence, but 2 died of neck metastasis and 2 of distant metastasis. The 5–year disease specific survival rate was 93.8%. Lugol's staining during surgery can reduce local recurrence and improve survival in patients with early tongue SCC.