Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling
Journal of Oral Pathology & Medicine, 06/08/2012
Nandula SR et al. – The data demonstrate that a combined action of type I interferon (IFN) and IL–6 contributes toward salivary gland hypofunction. This happens through interference with Ca2+ mobilization within acinar cells. Thus, in acute viral infections and diseases like Sjögren’s syndrome, elevated levels of type I IFNs and IL–6 can directly affect glandular function.