COX/PGE2 axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps

Clinical & Experimental Allergy, 04/18/2012

The results suggest that the regulatory effects of lipopolysaccharide (LPS) on eosinophilic airway inflammation are controlled via the COX–2/PGE2 axis. For clinical implications, indiscreet use of non–steroidal anti–inflammatory drugs should be avoided in patients with CRSwNP.

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